Morphological differences in macrophages are critical for understanding their diverse functions and roles in the immune system. Analyzing these variations can provide insights into how macrophages respond to different stimuli and environments. Researchers typically examine features such as cell size, shape, and surface markers to identify distinct macrophage subsets. Understanding these morphological characteristics aids in deciphering the relationship between macrophage phenotype and function, which is essential for developing targeted therapies in inflammatory diseases, infections, and cancer.