Human alveolar macrophages are crucial for respiratory health and immune defense in the lungs. These specialized immune cells reside in the alveoli and play a key role in maintaining lung homeostasis by clearing pathogens and debris. They are instrumental in the inflammatory response and are involved in conditions such as asthma, pneumonia, and chronic obstructive pulmonary disease (COPD). Studying human alveolar macrophages provides valuable insights into pulmonary diseases and aids in the development of targeted therapies to enhance lung function and immunity.