A major point of interest is Fc region glycosylation. The Fc, or fragment crystallizable region of immunoglobulin G (IgG), houses conserved N-linked glycans that are key regulators of immune effector functions such as antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), and anti-inflammatory responses. Even subtle changes in the glycan profile—such as variations in fucosylation, galactosylation, or sialylation—can significantly shift biological activity. At Creative Biolabs, they offer an advanced Fc glycosylation analysis service that combines cutting-edge techniques to assess the glycosylation status of biopharmaceuticals. Using mass spectrometry (MS), high-performance liquid chromatography (HPLC), and lectin-based assays, they provide comprehensive insights into the glycan structures attached to the Fc region of antibodies.